01 - Pat the catfish fillets completely dry using paper towels. Season both sides of each fillet evenly with salt, black pepper, and Cajun seasoning, pressing gently to adhere.
02 - In a shallow bowl, whisk together the eggs and buttermilk until fully combined and smooth.
03 - In a separate wide bowl, combine the cornmeal, all-purpose flour, paprika, garlic powder, and onion powder. Mix thoroughly to distribute spices evenly.
04 - Dip each seasoned fillet into the egg-buttermilk mixture, allowing excess to drip off. Transfer immediately to the cornmeal mixture and dredge generously, pressing lightly to ensure the coating adheres firmly to all surfaces.
05 - Pour vegetable oil into a heavy skillet or deep fryer to a depth of at least 2 inches. Heat to 350°F, monitoring with a thermometer to maintain consistent temperature.
06 - Cook fillets in batches without overcrowding the pan. Fry for 3–4 minutes per side until golden brown and completely cooked through. The internal temperature should reach 145°F.
07 - Transfer finished fillets to a wire rack or paper towels to drain excess oil. Let rest for 2–3 minutes before serving.
08 - Plate the fried catfish while hot, accompanied by lemon wedges, tartar sauce, and traditional Southern sides such as coleslaw, hush puppies, or French fries.